To study the drug resistant phenotype between stem-like cancer cells at different EMT status, we isolated 4 subpopulations from the non-small-cell lung cancer cell line (PC14) according to the E-cadherin and CD133 expression level. We demonstrated that the epithelial type CD133high stem-like cells (E-cadhighCD133high) significantly exhibited higher drug resistant ability compared to the mesenchymal type CD133high stem-like cells (E-cadlowCD133high), epithelial type CD133low non-stem like cells (E-cadhighCD133low) and mesenchymal type CD133low non-stem like cells (E-cadlowCD133low).
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Cell line
View SamplesPGG is a natural product exhibits anti-cancer effects on different type of cancers including liver cancer cell lines. In present study we identified a set of genes affected by PGG treatment in Huh7 cells. Some of them, for example, control cell cycle and cell proliferation.
Induction of GNMT by 1,2,3,4,6-penta-O-galloyl-beta-D-glucopyranoside through proteasome-independent MYC downregulation in hepatocellular carcinoma.
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View SamplesWe have discovered that amiloride can produce a genome-wide effect on alternative splicing of various RNA transcripts, most importantly including those of the apoptotic factors, in K562 leukemic cells.
Amiloride modulates alternative splicing in leukemic cells and resensitizes Bcr-AblT315I mutant cells to imatinib.
Cell line
View SamplesWith the aging population, there is a growing focus on dementia, especially Alzheimers disease (AD). The molecular basis underlying the pathogenesis of AD is gradually being elucidated. Increasing evidence has shown that the immunological function of leukocytes plays a crucial role in the development of neurodegenerative disorders. However, there have been few studies among the Taiwanese population.
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Specimen part, Disease, Race
View SamplesTranscriptome analysis of pooled RNA samples from total WBC collection
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Specimen part, Disease, Disease stage
View SamplesExpression profiling of prostate carcinoma tissue samples of benign and metastatic in disease progression.
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No sample metadata fields
View SamplesMouse gene express was using Mouse Gene 1.0 ST Array.
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Specimen part
View SamplesActive HUMSC with distinct binding rate to MDA MB-231 breast cancer cells, distinct ability in suppressing tumorigenesis,distinct cell in cell features and distinct features under TEM then inactive HUMSC
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Specimen part
View SamplesThis study has been approved by the Medical Ethics Committee of the Southern Medical University. Written informed consent was provided by each patient and volunteer before sampling. Nine patients with SSNHL were included in this study, and 3 healthy volunteers were recruited as normal controls.
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Sex, Specimen part
View SamplesBcl-2-accociated transcription factor 1(BCLAF1) has been reported to be involved in diverse biological processes. Alternative splicing leads to mutiple transcript virants in human cells and we are interested in functions of its full length isoform(BCLAF1-L) in human colon cancer cells, thus to understanding its role in colon cancer progression.
BCLAF1 and its splicing regulator SRSF10 regulate the tumorigenic potential of colon cancer cells.
Specimen part, Cell line
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