Description
To study the drug resistant phenotype between stem-like cancer cells at different EMT status, we isolated 4 subpopulations from the non-small-cell lung cancer cell line (PC14) according to the E-cadherin and CD133 expression level. We demonstrated that the epithelial type CD133high stem-like cells (E-cadhighCD133high) significantly exhibited higher drug resistant ability compared to the mesenchymal type CD133high stem-like cells (E-cadlowCD133high), epithelial type CD133low non-stem like cells (E-cadhighCD133low) and mesenchymal type CD133low non-stem like cells (E-cadlowCD133low).