Amiloride modulates alternative splicing in leukemic cells and re-sensitizes Bcr-AblT315I mutant cells to imatinib

We have discovered that amiloride can produce a genome-wide effect on alternative splicing of various RNA transcripts, most importantly including those of the apoptotic factors, in K562 leukemic cells.

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Chang WH, Liu TC, Yang WK, Lee CC, Lin YH, Chen TY, Chang JG