We differentiated hESC into retinal pigment epithelial cells using two methods (three-dimensional culture and spontaneous differentiation methods). We investigated which kind of RPE cells derived from hESC showed similar gene expression patterns to those of human fetal native RPE.
No associated publication
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View SamplesMuscle development and growth is an economically important process in the pig.The neonatal period is another important stage for the pig when the most rapid gain occurring in skeletal muscle.Gene expresseion changes during fetal and postnatal skeletal muscle development that can be used to enhance pig production efficiency, as well as for comparative developmental biology using the pig as a model for other mammalian species.
Gene expression profiling of skeletal muscle of nursing piglets.
Specimen part
View SamplesA number of homeobox genes have been found to be implicated in the development of various cancers. Here, we investigated the role of engrailed 2 (EN2), a member of the homeobox gene superfamily, in esophageal squamous cell carcinoma
Engrailed-2 promotes a malignant phenotype of esophageal squamous cell carcinoma through upregulating the expression of pro-oncogenic genes.
Specimen part, Cell line
View SamplesWhole transcript expression analysis was performed on liver biopsy from wild mice,DEN model mice and cell-treated mice(2 mice per group)
Transplantation of periportal vessel stem cells promotes liver injury repair in cirrhotic mice
Age, Specimen part
View SamplesCaco-2 cells were infected with F. nucleatum (MOI=100:1) or non-infected (control) for 24 hours. Total RNA of cells was extracted using the TRIzol Reagent (Life Technologies) and cDNA was generated using the PimeScript TMRT Reagent Kit (Takara).
TLR2/TLR4 activation induces Tregs and suppresses intestinal inflammation caused by Fusobacterium nucleatum in vivo.
Specimen part, Cell line
View SamplesThis SuperSeries is composed of the SubSeries listed below.
No associated publication
Specimen part
View SamplesGlioblastoma is the most aggressive and lethal malignant brain tumor. Gene expression profiling is useful in determining the genome-wide gene expression changes based on the experimental purpose. In order to interrogate the downstream targets of PTPRZ1, we applied gene expression profiles to screen the altered genes that are responsible for the functional phenotype changes. The results will provide a cue for mechanical analysis with potential translational values.
No associated publication
Specimen part
View SamplesA predictive gene list for response to high dose melphalan therapy in patients diagnosed with multiple myeloma is generated by combining results from dose response experiments and microarray data using a B-cell line panel and the introduction of multivariate regression techniques.
Generation of a predictive melphalan resistance index by drug screen of B-cell cancer cell lines.
Cell line
View SamplesWe used microarrays to assess gene expression in patients with ET, PV, and PMF compared to control subjects
Whole-blood transcriptional profiling of interferon-inducible genes identifies highly upregulated IFI27 in primary myelofibrosis.
Specimen part, Disease
View Samplesusing peripheral blood monocytes to identify marker genes for an extensively grown coronary collateral circulation.
Non-invasive gene-expression-based detection of well-developed collateral function in individuals with and without coronary artery disease.
Sex, Age
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