submitter_institution:Nagasaki unversity Results

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Microarray (180)

Platform

Affymetrix Mouse Gene 1.0 ST Array (mogene10st) (90)

Affymetrix Human Gene 1.0 ST Array (hugene10st) (33)

Affymetrix Human Genome U133 Plus 2.0 Array (hgu133plus2) (21)

Affymetrix Mouse Gene 2.0 ST Array (mogene20st) (12)

Illumina HumanHT-12 V4.0 expression beadchip (reannotation) (10)

Illumina HumanRef-8 v3.0 expression beadchip (Search Key version) (8)

Includes Publication

GSE84968

Histone H2A T120 phophorylation promotes oncogenic transformation via upregulation of cyclin D1y

Mus musculus, Homo sapiens
8 Downloadable Samples
Illumina HumanRef-8 v3.0 expression beadchip

Description

This SuperSeries is composed of the SubSeries listed below.

Publication Title

Histone H2A T120 Phosphorylation Promotes Oncogenic Transformation via Upregulation of Cyclin D1.

Sample Metadata Fields

Specimen part, Cell line

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GSE84962

Genome-wide analysis of gene expression regulated by VRK1 kinase in cancer cell lines [Illumina]

Homo sapiens
8 Downloadable Samples
Illumina HumanRef-8 v3.0 expression beadchip

Description

Histone H2A T120 phosphorylation promotes oncogenic transformation via upregulation of cyclin D1

Publication Title

Histone H2A T120 Phosphorylation Promotes Oncogenic Transformation via Upregulation of Cyclin D1.

Sample Metadata Fields

Cell line

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GSE24553

Expression data of SAGM-grown cells derived thyroid follicular cells

Homo sapiens
5 Downloadable Samples
Affymetrix Human Genome U133 Plus 2.0 Array (hgu133plus2)

Description

We developed a novel culture system to obtain multilineage undifferentiated stem/progenitor cells from normal human thyroid tissues. This seems to be achieved by direct reprogramming of thyroid follicular cells. The objective of the study was to reveal gene expression profile of the obtained cells compared to primary thyrocytes. After enzymatic digestion, primary thyrocytes, expressing thyroglobulin and cytokeratin-18, were cultured in a serum-free medium called SAGM containing insulin and EGF. Although the vast majority of cells died, a small proportion (~0.5%) survived and proliferated. During initial cell expansion, thyroglobulin/cytokeratin-18 expression was gradually declined, suggesting that those cells are derived from thyroid follicular cells or at least thyroid-committed cells. The SAGM-grown cells did not express any thyroid-specific genes. However, after four-week incubation with FBS and TSH, cytokeratin-18, thyroglobulin, TSH receptor, PAX8 and TTF1 expressions re-emerged. Moreover, surprisingly, the cells were capable of differentiating into neuronal or adipogenic lineage depending on differentiating conditions.

Publication Title

Dedifferentiation of human primary thyrocytes into multilineage progenitor cells without gene introduction.

Sample Metadata Fields

Specimen part

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GSE100989

Gene Expression in the BAT and WAT of ob/ob and ob/ob/Cidea-/-/Cidec-/- mice

Mus musculus
12 Downloadable Samples
Affymetrix Mouse Gene 1.0 ST Array (mogene10st)

Description

ob/ob mice is an obese mice. CIDE family proteins including Cidea, Cideb and Cidec play important role in lipid metabolism. Cidea is mainly expressed in the brown adipose tissue (BAT). Cidec is mainly expressed in the BAT and white adipose tissue (WAT). We generated ob/ob/Cidea-/-/Cidec-/- mice to investigate the phenotype of fat tissue. ob/ob/Cidea-/-/Cidec-/- mice are lean when compared with ob/ob mice. The tissue weight and TAG content of BAT and WAT was extreamly decreased in ob/ob/Cidea-/-/Cidec-/- mice compared with that in ob/ob mice.

Publication Title

Coordination Among Lipid Droplets, Peroxisomes, and Mitochondria Regulates Energy Expenditure Through the CIDE-ATGL-PPARα Pathway in Adipocytes.

Sample Metadata Fields

Sex, Age, Specimen part

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GSE59807

Gene expression in the GWAT of ob/ob and ob/ob/Fsp27-/- mice

Mus musculus
6 Downloadable Samples
Affymetrix Mouse Gene 1.0 ST Array (mogene10st)

Description

GWAT store most of the TAG in mice, ob/ob mice is an obese mice. Ob/ob/Fsp27-/- mice are lean when compared with ob/ob mice. The GWAT weight was dramatically reduced in ob/ob/Fsp27-/- mice.

Publication Title

Insulin resistance and white adipose tissue inflammation are uncoupled in energetically challenged Fsp27-deficient mice.

Sample Metadata Fields

Sex, Age, Specimen part

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GSE75292

Genome-wide analysis of gene expression by miR-204/211 in normal breast cell line MCF10A and breast cancer cell line MCF7

Homo sapiens
6 Downloadable Samples
Illumina HumanHT-12 V4.0 expression beadchip

Description

Genome-wide expression analysis of MCF-10A and MCF-7 where miR-204 and miR-211 are overexpressed. The characteristics of differentially expressed genes in both cell lines derives the cells toward being oncogenic.

Publication Title

Genome-wide identification of target genes for miR-204 and miR-211 identifies their proliferation stimulatory role in breast cancer cells.

Sample Metadata Fields

Sex, Specimen part, Cell line

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GSE85247

Epigenetically regulated Fibronectin leucine rich transmembrane protein 2 (FLRT2) shows tumor suppressor activity in breast cancer cells

Homo sapiens
4 Downloadable Samples
Illumina HumanHT-12 V4.0 expression beadchip

Description

To investigate the role of FLRT2 in breast cancer, its expression was knocked down and upregulated in mammary cell lines. Our results show that FLRT2 has tumor suppressor activity in breast cancer.