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GSE54024
Caenorhabditis elegans
22 Downloadable Samples
Affymetrix C. elegans Genome Array (celegans)
Description
We have shown that worms that possess mutations in two electron transport chain subunits live longer due to mtROS signalling. Wild type worms can also live longer by treatment with the pro-oxidant paraquat. Paraquat treatment is not additive to the mutations in the ETC subunits. We aimed to determine the underlying changes in gene expression that were common to both paraquat treatment and the two mutations.
Publication Title
The intrinsic apoptosis pathway mediates the pro-longevity response to mitochondrial ROS in C. elegans.
Sample Metadata Fields
Sex
View Samples- Mus musculus
- 8 Downloadable Samples
Illumina HiSeq 2500
Description
We use single-cell RNA-seq to determine distinct selection phenotypes of 2 rare thymic Treg cell progenitors as well as mature thymic Treg cells Overall design: A single cell suspension was generated from murine thymus then magnetically depleted for CD8/Ter119 before sorting CD25+Foxp3-, CD25-Foxp3lo and CD25+Foxp3+ cells from CD4+CD73- thymocytes on a BD Aria II. The 10x Genomic platform…
Publication Title
Thymic regulatory T cells arise via two distinct developmental programs.
Sample Metadata Fields
Age, Cell line, Subject
View Samples- Homo sapiens
- 77 Downloadable Samples
- Affymetrix Human Exon 1.0 ST Array [probe set (exon) version (huex10st)
Description
These colorectal cancer (CRC) samples have been analyzed by exon expression profiling to identify genes with overexpression of 3 parts. By characterizing underlying transcript structures of such genes with a combination of rapid amplification of cDNA ends and deep-sequencing (RACE-seq), we identify and describe novel RNA-variants in CRC.
Publication Title
Novel RNA variants in colorectal cancers.
Sample Metadata Fields
Specimen part
View Samples