To identify genes expressed in specific developing thalamic nuclei during embryonic stages, a genetic dual labelling strategy was established to mark and isolate the cells. Transcription profiles were determined for the principal sensory thalamic populations by genome-wide analysis.
Genetic Labeling of Nuclei-Specific Thalamocortical Neurons Reveals Putative Sensory-Modality Specific Genes.
Specimen part
View SamplesMisguided visual thalamic axons leads to changes in gene expression in visual thalamic neurons.
Genetic Labeling of Nuclei-Specific Thalamocortical Neurons Reveals Putative Sensory-Modality Specific Genes.
Specimen part
View SamplesElimination of peripheral retinal axons leads to changes in gene expression in both visual and somatosensory thalamic neurons.
Prenatal thalamic waves regulate cortical area size prior to sensory processing.
Specimen part
View SamplesWe elucidate a neurological syndrome affecting both the PNS and CNS defined by CLP1 mutations that impair tRNA splicing Overall design: Identification and biochemical characterization of mutant CLP1 in human patients
Human CLP1 mutations alter tRNA biogenesis, affecting both peripheral and central nervous system function.
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