Gene expression profile between Parp-2-/- and wild-type hematopoietic stem/progenitor cells at basal and to the early response (2.5 hours) to 5 Gy total body irradiation
Parp-2 is required to maintain hematopoiesis following sublethal γ-irradiation in mice.
Specimen part
View SamplesWe treated 80% confluent J774A.1 macrophages with 1 nM neuropeptide-FF (NPFF) for 18 h.
Neuropeptide FF increases M2 activation and self-renewal of adipose tissue macrophages.
Treatment
View SamplesIn addition to the recently published in situ transcriptomics of LCL skin lesions (Novais et al., Khouri et al.), we herein present the first systemic disease signature of localized cutaneous leishmaniasis (LCL), using Affymetrix microarrays (HuGene 1.0) followed by systems biology analysis of the PBMC transciptome of LCL patients (n=18), as compared to healthy controls (n=12).
Systems Approach Reveals Nuclear Factor Erythroid 2-Related Factor 2/Protein Kinase R Crosstalk in Human Cutaneous Leishmaniasis.
Specimen part, Disease stage
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