Transcriptional profiles of lung macrophage subsets in Mycobacterium Tuberculosis infection

We investigated transcriptional responses of different lung macrophage lineages during M.tuberculosis infection by RNAseq. Our data revealed that different lineages of macrophages respond differentially to M.Tuberculosis infection. Overall design: Alveolar macrophage (AM) and interstitial macrophages (IM) with or without Mtb were FACS-sorted from Mtb infected mice for RNAseq.

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Huang L, Nazarova EV, Tan S, Liu Y, Russell DG