Catch-and-release of cytokines converts transient exposure into long-term inflammatory responses

We report that after cancer cells are exposed to a transient pulse (5h) of the pro-inflammatory cytokine IFN?, they continue up-regulating genes in the antigen presentation pathway for days after abrogation of the original signal. We discovered that a new mechanism of cell-to-cell communication, cytokine catch-and-release, explains this surprising result. Overall design: Examination of IFN?-induced gene expression over multiple timepoints in mouse melanoma cells

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Oyler-Yaniv J, Oyler-Yaniv A, Shakiba M, Min NK, Chen YH, Cheng SY, Krichevsky O, Altan-Bonnet N, Altan-Bonnet G