Impact of Lef1 overexpression on follicular helper T (Tfh) differentiation

SRP056606

Mus musculus

8 Downloadable Samples

Illumina HiSeq 2500

Submitter Supplied Information

Description

Comparison of transcriptome between GFP-RV+ Th1 cells and Lef1-RV+ Th1 cells Overall design: B6 mice received GFP-RV+ or Lef1-RV+ LCMV gp specific TCRtg Smarta cells and were infected with LCMV. On four days after infection, splenocytes were collected to sort CXCR5- Th1 cells per genotype. Contributor: LIAI RNAi Center (LIAI)

PubMed ID

26214741

Publication Title

LEF-1 and TCF-1 orchestrate T(FH) differentiation by regulating differentiation circuits upstream of the transcriptional repressor Bcl6.

Total Samples

Submitter’s Institution

No associated institution

Authors

Choi YS, Gullicksrud JA, Xing S, Zeng Z, Shan Q, Li F, Love PE, Peng W, Xue HH, Crotty S

Source Repository

Sequence Read Archive (SRA)

No rows found