Expression data from mouse hair follicle stem cells at postnatal day 49 in K14-sPLA2-IIA and wild type mice

sPLA2-IIA is involved in lipid catabolism and is deregulated in various human cancers. Our data showed that over expression of sPLA2-IIA in skin disrupts various epidermal lineages, loss of ortho-parakeratotic organization, stem cell depletion/quiescence and increased differentiation potentially associated with global differences in epigenetic status. Our study has provided significant contribution to over existing knowledge of sPLA2-IIA by showing the unexplored role of sPLA2-IIA in hair follicle stem cells and skin homeostasis mediated through JNK/c-Jun signaling mechanism.

6