Genome-wide monitoring of gene expression in Saccharomyces cerevisiae upon KP1019 treatment

KP1019 (trans-[tetrachlorobis(1H-indazole) ruthenate(III)]) is a ruthenium complex that exhibited anti-cancer activity in several in vitro and in vivo studies. KP1019 was even efficient against cancer cells that were resistant to other chemotherapeutic agents and thus emerged as a promising anti-cancer drug without dose-limiting cytotoxicity. However, the molecular mechanisms of its action are elusive.

4

Golla U, Swagatika S, Chauhan S, Tomar RS