Expression data in histone-depleted cells [gene-level]

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GSE69307

Homo sapiens

6 Downloadable Samples

Affymetrix Human Transcriptome Array 2.0 (hta20)

Submitter Supplied Information

Description

How chromatin controls transcription elongation and splicing is an open question. Here we determine the transcriptomic changes of cells partially depleted of core histones. For that we construct a cell line with Doxycycline-controlled levels of the histone regulatory protein SLBP (HCT-shSLBP). HCT-shSLBP is derived from the human colon cancer cell line HCT116.

PubMed ID

26578803

Publication Title

Defective histone supply causes changes in RNA polymerase II elongation rate and cotranscriptional pre-mRNA splicing.

Total Samples

Submitter’s Institution

CABIMER

Authors

Jimeno-González S, Payán-Bravo L, Muñoz-Cabello AM, Guijo M, Gutierrez G, Prado F, Reyes JC

Source Repository

Gene Expression Omnibus (GEO)

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