Differential gene expression in placentae (E10.5) from adra2bKO and adra2bWT mice

alpha2-adrenoceptors are essential presynaptic regulators of norepinephrine release from sympathetic nerves. Previous studies in mice with targeted deletions in the three alpha2-adrenoceptor genes have indicated that these receptors are essential for embryonic development. In the present study, we searched for the alpha2-adrenoceptor subtype(s) involved in placental development and its molecular mechanism using mice carrying targeted deletions in alpha2-adrenoceptor genes.

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Muthig V, Gilsbach R, Haubold M, Philipp M, Ivacevic T, Gessler M, Hein L