A transcriptional signature of fatigue derived from patients with primary Sjgren's Syndrome

Fatigue is a debilitating condition with a significant impact on patients quality of life. Fatigue is frequently reported by patients suffering from primary Sjo grens Syndrome (pSS), a chronic autoimmune condition characterised by dryness of the eyes and the mouth. However, although fatigue is common in pSS, it does not manifest in all sufferers, providing an excellent model with which to explore the potential underpinning biological mechanisms.

160