Expression data of untreated or cisplatin-treated wildtype or Rb-/- MEFs

The absence of the Rb tumor suppressor gene changes levels/activities of transcription factors (e.g., E2F and p53) which alter gene expression patterns, related to cell cycle control and cellular response to DNA damage. Cisplatin is a genotoxic chemotherapeutic agent and wildtype or Rb null cells have different sensitivities to cisplatin-induced cytotoxicity.

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Liu H, Knabb JR, Spike BT, Macleod KF