Gene expression profiling of cardiac-specific overexpression of TNF- in Des-/- myocardium

Tumor Necrosis Factor- is greatly implicated in heart pathophysiology, while it is upregulated in the failing myocardium. A major target in TNF--induced heart failure is the muscle specific intermediate filament cytoskeleton, comprised by desmin. We analysed the effect of cardiac-specific overexpression of TNF- in the Des-/- myocardium, which is a known model of dilated cardiomyopathy.

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