Basonuclin-1 modulates epithelial plasticity and TGF-1-induced loss of epithelial cell integrity [BNC1]

TGF-b1-stimulation induces an epithelial dedifferentiation-process, throughout which epithelial cell sheets disintegrate and gradually switch into fibroblastic-appearing cells (EMT-like transition). Several transcription factors, some of them being TGF-b1-responsive, are functionally involved in such a switch and affect epithelial differentiation and plasticity.

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Feuerborn A, Mathow D, Srivastava PK, Gretz N, Gröne HJ