Gene expression profiles in the colon of APC and Olfm4 double mutant mice

APC mutant mice develop polys in the intestine, but not carcinoma. We found that additional deletion of Olfm4 gene induced carcinoma formation in the distal colon. To explore the molecular mechanism, we performed cDNA microarray to understand the gene expression files in the tumor tissues compared with WT, APC mutant and Olfm4 mutant mice.

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Liu W, Li H, Hong SH, Piszczek GP, Chen W, Rodgers GP