Gene expression in mouse hematopoietic stem and multi-potent progenitor cells with temporally defined divisional histories

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GSE48261

Mus musculus

14 Downloadable Samples

Affymetrix Mouse Genome 430 2.0 Array (mouse4302)

Submitter Supplied Information

Description

Homeostatic hematopoietice stem cells (HSCs) with greater divisional history lose repopulating potential after very few cell divisions. Divisional history overrides both phenotype and immediate quiescence in determining functional activity. In GFP label retaining system GFP is progressively diluted when cells proceed through a cascade of divisions.

PubMed ID

24749072

Publication Title

Divisional history and hematopoietic stem cell function during homeostasis.

Total Samples

Submitter’s Institution

Icahn School of Medicine at Mount Sinai

Authors

Qiu J, Papatsenko D, Niu X, Schaniel C, Moore K

Source Repository

Gene Expression Omnibus (GEO)

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