Expression Profiles of E11.5 Mouse Optic Fissure

Mice that are mutant for both Fgfr1 and Fgfr2 specifically in the developing retina develop coloboma. To analyze the transcripts that are affected by defective FGF signaling, we micro-dissected the optic fissure region from the control and FGFR condtional mutant mice and did microarray analysis.

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Chen S, Li H, Gaudenz K, Paulson A, Guo F, Trimble R, Peak A, Seidel C, Deng C, Furuta Y, Xie T