Expression data from the adult hippocampus of Sox1-GFP mice

The dentate gyrus of the hippocampus continues generating new neurons throughout life. These nerve cells originate from radial astrocytes within the subgranular zone (SGZ). We find that Sox1, a member of the SoxB1 family of transcription factors, is expressed in a subset of radial astrocytes. Lineage tracing using Sox1 driven reporter mice shows that the Sox1-expressing cells represent an activated neural stem/progenitor population.

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Venere M, Han YG, Bell R, Song JS, Alvarez-Buylla A, Blelloch R