Progression of ductal carcinoma in situ to invasive breast cancer

Ductal carcinoma in situ (DCIS) is a precursor lesion that can give rise to invasive breast cancer (IBC). It has been proposed that both the nature of the lesion and the tumor microenvironment play key roles in progression to IBC. Here, laser capture microdissected tissue samples from epithelium and stroma in normal breast, pure DCIS, and pure IBC were employed to define key gene expression profiles associated with disease progression.

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Knudsen ES, Ertel A, Davicioni E, Kline J, Schwartz GF, Witkiewicz AK