Expression analysis of mouse embryo fibrobalsts lacking Tgif1

Tgif1 is a transcriptional corepressor that limits TGF responsive gene expression. TGF signaling has antiproliferative effects in several cell types, generally resulting in a G1 arrest. Mouse embryo fibroblasts (MEFs) are primary cells with limited life-span, that senesce after several passages in culture.

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Zerlanko BJ, Bartholin L, Melhuish TA, Wotton D