Transcriptional changes in the absence of nth-1, xpa-1 and nth-1;xpa-1

Background: The ability of an organism to repair damages to DNA is inextricably linked to aging and cancer. We have characterized and compared the transcriptome of C. elegans mutants deficient in DNA base excision repair, nucleotide excision repair or both to elucidate the transcriptional changes incurred by the reduction of these repair pathways.

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Fensgård Ø, Kassahun H, Bombik I, Rognes T, Lindvall JM, Nilsen H