Depletion of Erk1 and Erk2 MAP kinases in primary human keratinocytes

We assessed the effect of RNAi-mediated MAP kinase cascade signaling blockade in primary human keratinocytes. Two sets of siRNA targeting different regions of the Erk1/2 genes were used, enabling identification of off-target siRNA effects.

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Dumesic PA, Scholl FA, Barragan DI, Khavari PA