GSE117774Effect of DGAT knockdown on gene expression in A498 xenograft tumors
Homo sapiens
8 Downloadable Samples
Affymetrix Human Transcriptome Array 2.0 (hta20)Submitter Supplied Information
Description
The metabolic enzyme diglyceride acyltransferase (DGAT) is responsible for the synthesis of triglycerides. Loss of its expression may sensitize cells to conditions of nutrient and oxygen that are commonly present in tumors. This study is designed to identify stress response pathways that may be induced following the shRNA-mediated knockdown of the two genes coding for the DGAT enzymes.
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A498 DGAT1/2 shRNA xenograft, 200mg/kg doxycycline chow, 5 days, biol repl 2
a498 xenograft tumor
doxycycline
A498 DGAT1/2 shRNA xenograft, 200mg/kg doxycycline chow, 5 days, biol repl 3
a498 xenograft tumor
doxycycline
A498 DGAT1/2 shRNA xenograft, 200mg/kg doxycycline chow, 5 days, biol repl 4
a498 xenograft tumor
doxycycline
A498 DGAT1/2 shRNA xenograft, 200mg/kg doxycycline chow, 5 days, biol repl 1
a498 xenograft tumor
doxycycline
A498 DGAT1/2 shRNA xenograft, control chow, 5 days, biol repl 4
a498 xenograft tumor
vehicle
A498 DGAT1/2 shRNA xenograft, control chow, 5 days, biol repl 3
a498 xenograft tumor
vehicle
A498 DGAT1/2 shRNA xenograft, control chow, 5 days, biol repl 1
a498 xenograft tumor
vehicle
A498 DGAT1/2 shRNA xenograft, control chow, 5 days, biol repl 2
a498 xenograft tumor
vehicle
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