Regulation of the early embryonic RPE (retinal pigment epithelium) transcriptome by the neural retina

Purpose: The retinal pigment epithelium (RPE) forms the outer blood-retinal barrier. Primary cultures of RPE can model the barrier, but are very sensitive to culture conditions. We examined how the neural retina regulates the RPE transcriptome in a culture model of embryonic development. Attention focused on the tight junctional genes essential for barrier function.

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Sun R, Peng S, Chen X, Zhang H, Rizzolo LJ